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產品概述
| 名稱 | BV2 (小鼠小膠質細胞) (種屬鑒定正確) |
| 別稱 | BV-2 |
| 種屬 | 小鼠 |
| 年齡（性別） | 不詳 |
| 組織來源 | 腦；膠質瘤 |
| 生長特性 | 半貼半懸 |
| 細胞形態 | 上皮細胞樣 |
| 背景描述 | BV-2細胞是由E·Blasi建立于1990年；BV-2細胞由小鼠小神經膠質細胞經逆轉錄病毒介導轉染v-raf/v-myc獲永生化。BV-2細胞保留有小神經膠質細胞多種形態、表征和功能特征；免疫組化結果顯示，BV-2細胞為MAC1、MAC2陽性；而MAC3、膠質細胞原纖維酸性蛋白、半乳糖腦苷脂為陰性。 |
| 生長培養基 | MEM＋10% FBS＋1% P/S |
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2~3次/周 |
| 凍存條件 | 凍存液：55% 基礎培養基+40%FBS+5%DMSO 溫度：液氮 |
| 培養條件 | 氣相：空氣，95%；CO2，5% 溫度：37℃ |
STR鑒定
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STR位點信息
18-3 16,17 9-2 17.3 6-7 15 5-5 17 X-1 27 15-3 22.3,23.3,24.3 12-1 17 6-4 18 4-2 20.3 jaridl X -
STR鑒定圖
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參考文獻
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NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma(2020/4/15)
作者：Hui Chen, Yang Deng, Xiaoliang Gan
期刊：Molecular Neurodegeneration
DOI：10.1186/s13024-020-00372-w
影響因子 ：14.195
引用產品：CL-0493
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The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis(2021/5/20)
作者：Yang Deng, Yunzhao Fu, Longxiang Sheng
期刊：Frontiers in Cell and Developmental Biology
影響因子 ：6.684
引用產品：CL-0493
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Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia(2021/03/13)
作者：Yan Zhao, Xialin Sun, Tingwen Zhang
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111387
影響因子 ：6.529
引用產品：CL-0493
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Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents(2020/09/28)
作者：Min Wang, Tongtong Liu, Shiming Chen
期刊：European Journal Of Medicinal Chemistry
DOI：10.1016/j.ejmech.2020.112874
影響因子 ：6.514
引用產品：CL-0493
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DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84(2020/12/3)
作者：Wenshuang Gao, Yujuan Qu, Juan Huai
期刊：Aging-US
影響因子 ：5.682
引用產品：CL-0493
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The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway(2020/9/19)
作者：Xialin Sun, Tingwen Zhang, Yan Zhao
期刊：Phytomedicine
DOI：10.1016/j.phymed.2020.153348
影響因子 ：5.34
引用產品：CL-0493
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Mafenide derivatives inhibit neuroinflammation in Alzheimers disease by regulating pyroptosis(2021/10/10)
作者：Chenyang Han, Qiaohong Hu, Anqi Yu
期刊：Journal Of Cellular And Molecular Medicine
影響因子 ：5.31
引用產品：CL-0493
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Serum Extracellular Vesicle–Derived miR-124-3p as a Diagnostic and Predictive Marker for Early-Stage Acute Ischemic Stroke(2021/7/1)
作者：Zheng Qi, Yingying Zhao, Yu Su
期刊：Frontiers in Molecular Biosciences
影響因子 ：5.246
引用產品：CL-0493
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Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinsons disease(2019.03.14)
作者：Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
期刊：Life Sciences
影響因子 ：5.037
引用產品：CL-0493
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Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors(2020.04.30)
作者：Chenyang Han, Yi Yang, Anqi Yu
期刊：European Journal of Pharmaceutical Sciences
DOI：10.1016/j.ejps.2020.105303
影響因子 ：4.384
引用產品：CL-0493
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A Causal Relationship in Spinal Cord Injury Rat Model Between Microglia Activation and EGFR/MAPK Detected by Overexpression of MicroRNA-325-3p(25 March 2019)
作者：Penghui Yan, Xuejian Wu, Xiaokang Liu, Yingchun Cai
期刊：Journal of Molecular Neuroscience
DOI：10.1007/s12031-019-01297-w
影響因子 ：3.444
引用產品：CL-0493
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Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture(May 20, 2020)
作者：Zhidong Zhou, Hejian Li, Hongchun Li
期刊：Molecular Medicine Reports
影響因子 ：2.952
引用產品：CL-0493
